عنوان مقاله
درمان هایپر ترمیای بافت های تومور با گرمادهی مستقیم لیزر و نانوذرات طلا
فهرست مطالب
مقدمه
معادله زیستی-حرارتی
حرارت دهی لیزری مستقیم
اشعه دهی غیر مستقیم توسط نانوذرات طلا
کاربردها
نتیجه گیری
بخشی از مقاله
حرارت دهی لیزری مستقیم
فرایند های حرارت دهی در زمانt = 0 با انداختن اشعه لیزر روی تومور آغاز می شود. حل این مسئله مستلزم داشتن دانش اولیه از توزیع دماییT(r,t=0)-T0(r) است که به خواص ترموفیزیکی و بیولوژیکی تومور علاوه بر شرایط محیطی حساس است.
کلمات کلیدی:
On the Hyper Thermal Therapy of Tumor Tissues by Direct Laser Heating and Gold Nano Particles Badiaa Fasla, Reda Benmouna, Mustapha Benmouna Macromolecular Research Laboratory, Department of Physics, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria. Email: redabenmouna@yahoo.com Received November 11th, 2013; revised December 17th, 2013; accepted January 6th, 2014 Copyright © 2014 Badiaa Fasla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accordance of the Creative Commons Attribution License all Copyrights © 2014 are reserved for SCIRP and the owner of the intellectual property Badiaa Fasla et al. All Copyright © 2014 are guarded by law and by SCIRP as a guardian. ABSTRACT Hyper thermal therapy using lasers is emerging as a new promising route for the cancer treatment. The tumor can be directly heated by the radiation or indirectly using gold nano particles based on plasmon resonance phenolmenon. These two possibilities are explored here by solving the space and time dependent bio-heat equation under different conditions. The knowledge of temperature profiles in the tumor region helps to bypass the painful placement of sensors for monitoring tumor’s heating by the laser. Important properties which could be useful for developing an efficient tumor therapy are introduced for the first time. It is found that the effects of metabolism consist essentially in a redefinition of the blood temperature which increases proportional to the heat of metabolism. Blood perfusion in a given tissue leads to a new characteristic length of order one or two centimeters and a blood convection parameter typically of order 30 W∙m−1 ∙K−1 . Effects of these parameters are scrutinized within the resolution of the bio-heat equation under a variety of conditions. In general, space modulations of the temperature throughout biological tissues are weak but front kinetics are quite fast. Specific examples show the way to monitor the temperature rise taking into account the tumor’s nature and size. KEYWORDS Hyper Thermal Therapy; Gold Nano Particles; Plasmon Resonance; Laser Heating 1. Introduction This paper deals with the temperature modeling in connection with hyper thermal therapy using laser radiation to heat up and eliminate tumor tissues in biological organs. Cells in tumor tissues are more sensitive to heating and show compact conformations as compared to healthy ones leading to inhibition of normal circulation of nutrients and oxygen in tumor cells. In addition, this behavior can be used to develop therapy strategies with the capability of differentiating between tumor and healthy tissues and tuning interactions between lasers and biological tissues to generate adequate responses. The energy deposited into biological tissues by short wavelength high energy lasers exceeds their binding energy which means that these lasers can be used to remove micron sized tumors. Photosensitive dyes provide the possibility to turn to lasers with a lower power and wavelength is adapted to the absorption spectra of the dyes [1-4]
